The An introduction number of genetic single nucleotide polymorphisms (SNPs) at the promoter region of HLA-DQB1 gene

Abstract

Human leukocyte antigen-DQB1 (HLA-DQB1, OMIM: 604305) is the human major histocompatibility complex (MHC) system, belonging to the class II human major histocompatibility complex (MHC). This complex of genes is centrally involved in the actions of the human immune system. They play an important role in donor-recipient matching in transplantations and can be associated with most autoimmune diseases. The aim of the present study was to introduce the HLA-DQB1 unsearched frequent SNPs that may associate induced with the risk. Previous studies have shown genetic polymorphisms in the promoter region of other genes change the gene expression. We suggest that HLA-DQB1 gene numbers of unsearched single nucleotide frequent polymorphisms such as rs3891175, rs9274526, rs71542466, and rs9274526 are highly frequent in worldwide populations may alter the HLA-DQB1 gene activity and subsequently may associate with risk of autoimmune diseases, especially viral related disease. For this suggest more research is needed to support this study in the future.